S.E.M.I. – Side Effects May Include...
S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!
85.8Rating
0Content
9Achievements
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About This Game
S.E.M.I. – Side Effects May Include... is a action/indie game with both single-player and multiplayer modes, developed by Two Horn Unicorn and released in 2026. With an estimated 6,000 copies sold, it is considered a niche release on Steam. Community ratings across Steam average 85.8/100 — a strong reception overall. The game has 3 DLCs available, expanding the base experience with additional content. Players commonly describe it as Co-op, Platformer, Physics, Multiplayer and Online Co-Op.
Media
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User Reviews
85.8
Overall Score / 100
8.6/10
Steam (113 reviews)
DLCs (3)
S.E.M.I. – Side Effects May Include Soundtrack
$1.99
S.E.M.I. – Side Effects May Include Christmas Soundtrack
$0.99
S.E.M.I. – Side Effects May Include: Digital Artbook
$1.99
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Game Information
Release Date
January 23, 2026
Developer
Two Horn Unicorn
Publisher
Two Horn Unicorn
Platforms
Windows
Controller
Full Support
Price
$7.99
Analytics & Metrics
Copies Sold (VISE)
Low Data
VRI ScoreLearning
N/A
VRI (Vorythic Recommendation Index) a single number indicating whether the game is worth your time. Built from game data, putting real players' opinions above progressive 'critics'.
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System Requirements
🪟 Windows
Minimum
- Requires a 64-bit processor and operating system
- OS: Windows 10
- Processor: Intel Core i5 series or Ryzen series
- Memory: 8 GB RAM
- Graphics: GTX 960 or AMD R9 290
- DirectX: Version 11
- Storage: 3 GB available space
Recommended
- Requires a 64-bit processor and operating system
- OS: Windows 11
- Processor: Intel Core i7 series or Ryzen series
- Memory: 8 GB RAM
- Graphics: GTX 1660 or RX6600
- DirectX: Version 12
- Storage: 3 GB available space
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